Research Project: Early diagnosis of Parkinson's

Diagnosis of people with mild Parkinson’s symptoms is difficult. Nevertheless, variations in gait pattern can be utilised to this purpose, when measured via Inertial Measurement Units (IMUs). Human gait, however, possesses a high degree of variability across individuals, and is subject to numerous nuisance factors. Therefore, off-the-shelf machine learning techniques may fail to classify it with the accuracy required in clinical trials.
In this project we propose a novel framework in which IMU gait measurement sequences sampled during a 10 metre walk are first encoded as hidden Markov models (HMMs) to extract their dynamics and provide a fixed-length representation. Given sufficient training samples, the distance between HMMs which optimises classification performance is learned and employed in a classical Nearest Neighbour classifier. Our tests demonstrate how this technique achieves accuracy of 85.51% over a 156 people with Parkinson’s with a representative range of severity and 424 typically developed adults, which is the top performance achieved so far over a cohort of such size, based on single measurement outcomes. The method displays the potential for further improvement and a wider application to distinguish other conditions.
Relevant Papers

 Fabio Cuzzolin, Michael Sapienza, Patrick Esser, Suman Saha, Marloes Franssen, Johnny Collett and Helen Dawes
Metric learning for Parkinsonian identification from IMU gait measurements
Gait and Posture, Volume 54, pages 127-132, May 2017
Project Partners

Professor Helen Dawes, Director of the Centre for Movement, Occupational and Rehabilitation Sciences (MOReS)